The Ireland midfielder, who has played two full games for his country despite being an injury doubt, will lead his side out at Molineux.
Addicks boss Alan Pardew is expected to make a couple of changes from the side that dropped two points in the last minutes against Barnsley.
Skipper Fit For Wolves Trip
Winger Jerome Thomas made an impact against the Tykes and should replace a struggling Darren Ambrose.
The other change could see on-loan defender Sam Sodje replace Jonathan Fortune who came off ill in the draw at The Valley.
With Ben Thatcher still sidelined and Cory Gibbs out for the season, veteran Chris Powell should remain at left-back, but youngster Grant Basey may be on the bench.
Possible side for Wolves: Weaver, Mills, Sodje, Bougherra, Powell, Thomas, Semedo, Zheng, Reid (C), Iwelumo, Varney
Subs: Randolph, Fortune, Racon, Todorov, McLeod
Possible side for
The other change could see on-loan defender Sam Sodje replace Jonathan Fortune who came off ill in the draw at The Valley.
With Ben Thatcher still sidelined and Cory Gibbs out for the season, veteran Chris Powell should remain at left-back, but youngster Grant Basey may be on the bench.
Possible side for Wolves: Weaver, Mills, Sodje, Bougherra, Powell, Thomas, Semedo, Zheng, Reid (C), Iwelumo, Varney
Subs: Randolph, Fortune, Racon, Todorov, McLeod
Possible side for