Appointed head coach at the Valley in January, things initially looked good for the Israeli as the Addicks finished 12th last season.
However, a horrid start to the Championship campaign has cost Luzon his job, with the club wielding the axe after Saturday's embarrassing 3-0 defeat to London rivals Brentford.
The head coach is followed out of the door by first-team coach David Martane and assistant head coach Damian Matthew, who has been at Charlton since arriving as a youth coach nine years ago.
"Given the recent downturn in results and following Saturday's 3-0 defeat to Brentford which leaves the Addicks in 22nd position, the board felt they had to make a change at this time," a club statetment read on www.cafc.co.uk.
"The club would like to thank the trio for their efforts and a further statement will be made in due course."
Luzon's exit is the fourth managerial change since Belgian businessman Roland Duchatelet took over the south London club in January 2014.
Chris Powell, Jose Riga and Bob Peeters have all come and gone, with Charlton now looking for a new manager once again.
Source : PA
Source: PA