He replaces the suspended Nicky Weaver in the Addicks goal, with Darren Randolph on the bench.
In defence, on loan Sam Sodje is out with a broken toe, so Madjid Bougherra returns alongside Paddy McCarthy.
Lee Cook was the unfortunate one last week against Plymouth, when sacrificed after three minutes for keeper Elliot, and he gets his chance on the left wing.
And upfront, theres no change, as Leroy Lita looks to continue his scoring run alongside Chris Iwelumo.
Possible side for Southampton: Elliot, Halford, Bougherra, McCarthy, Thatcher, Zheng, Semedo, Holland(C), Cook, Lita, Iwelumo
Subs: Randolph, Fortune, Thomas, Ambrose, Varney