Defender Doherty has shaken off a dead leg and midfielder Semedo has recovered from a hamstring injury.
Lee Martin is also fit after a hamstring problem, but the on-loan Ipswich midfielder is ineligible to play in the competition as is Plymouth loanee Marcel Seip.
Left-back Matt Fry is back after sitting out the original clash due to a one-match ban, but veteran centre-half Christian Dailly is still serving a four-match suspension.
Fry's return could see Johnnie Jackson, who has scored five goals in his last five games, revert from full-back to the left wing.
Academy youngsters Callum Harriott, Freddie Warren and Jordan Cousins could be on the bench again.
Source: PA
Source: PA